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Fundamentals of Asymmetric Catalysis

Patrick J. Walsh University of Pennsylvania
Marisa C. Kozlowski University of Pennsylvania

The field of asymmetric catalysis plays an increasingly large role in chemical synthesis as the demand for single-enantiomer starting materials, intermediates, and products rises. This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept is supported by carefully selected examples to give the reader broad exposure to a wide range of catalysts, reactions, and reaction mechanisms.

Print Book, ISBN 978-1-891389-54-2, US $116
eBook, eISBN 978-1-938787-55-3, US $87
Publish date: 2009
688 pages, Casebound

Summary

The field of asymmetric catalysis plays an increasingly large role in chemical synthesis as the demand for single-enantiomer starting materials, intermediates, and products rises. This book describes the essential aspects of enantioselective catalysis in a clear, logical fashion, with chapters organized by concept rather than by reaction type. Each concept is supported by carefully selected examples to give the reader broad exposure to a wide range of catalysts, reactions, and reaction mechanisms.

This book is designed to introduce advanced undergraduate or graduate chemistry students to asymmetric catalysis. It can be used as the primary text in a course on this topic, or as a reference by researchers who wish to increase their understanding. It is also intended for synthetic chemists who wish to increase their likelihood for success when faced with the prospect of using asymmetric catalysts.


Resources

List of Adoptions
Preface
Foreword
Index
View Chapter 4: Asymmetric Induction in Enantioselective Catalysis

Table of Contents

Contents
Introduction to Fundamentals of Asymmetric Catalysis
1. Modes of Asymmetric Induction
2. Lewis Acid and Lewis Base Catalysis
3. Beyond Lewis Acid and Lewis Base Catalysis
4. Asymmetric Induction in Enantioselective Catalysis
5. Nonclassical Two Point Catalyst Substrate Interactions
6. Chiral Poisoning, Chiral Activation, and Screening Achiral Ligands
7. Kinetic Resolution
8. Parallel Kinetic Resolution
9. Dynamic Kinetic Resolution and Dynamic Kinetic Asymmetric Transformations
10. Desymmetrization Reactions
11. Nonlinear Effects, Autocatalysis, and Autoinduction
12. Bifunctional, Dual, and Multifunctional Catalyst Systems
13. Asymmetric Catalysis with Homochiral Substrates: Double Diastereoselection
14. Multistep Asymmetric Catalysis
15. Supported Catalysts
16. Applications of Asymmetric Catalysis in Synthesis
Appendix
Index

Reviews

“This fascinating book captures the diversity and applicability of an area of research that has emerged as one of the fastest growing fields in organic chemistry. As a text that addresses the major concepts of asymmetric catalysis, it could serve as an excellent aid for a university course…this book is destined to become a firm favorite for advanced and graduate students. Additionally, the book can be recommended to all scientists in academia and industry with an interest in asymmetric catalysis–as a source of information and for references. [It] is worth the price and should appear on many bookshelves and in many libraries.”
-Angew. Chem. Int. Ed, 2009, 48

“It is my opinion that this text will be widely accepted by the organic chemical community. There is nothing like it currently on the market. It reminds me of the Morrison & Mosher text, Asymmetric Synthesis, that was published more than three decades ago. The authors have generated the “New Bible” of asymmetric catalysis. The results are truly impressive and the cases are both relevant and current.”
-David A. Evans, Harvard University

“This book is a great tool and “go to” book for students and practitioners interested in Asymmetric Synthesis.”
-Mukund Sibi, North Dakota State University

“This is an impressive piece of scholarship that will be welcomed by the catalysis community.”
-Jeffrey S. Johnson, University of North Carolina

Patrick J. Walsh University of Pennsylvania

Patrick J. Walsh is a Professor of Chemistry at University of Pennsylvania. He received his B.A. from UC San Diego, where he was mentored by Prof. Charles Perrin, and his Ph.D from UC Berkeley, where he studied organometallic chemistry with Prof. Robert G. Bergman. Following an NSF postdoctoral fellowship with Prof. K. B. Sharpless at the Scripps Research Institute, he moved across town to become an assistant professor at San Diego State University and a professor at Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana (Mexico). In 1999 he moved to his current position at the University of Pennsylvania where he is currently professor of chemistry. Walsh has received several awards, most recent of which was the 2006 Philadelphia Section Award of the ACS. Walsh’s interests are in asymmetric catalysis, development of new methods, reaction mechanisms, and inorganic synthesis.

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Marisa C. Kozlowski University of Pennsylvania

Marisa Kozlowski is a Professor of Chemistry at University of Pennsylvania. She received an A. B. in Chemistry from Cornell University and a Ph.D. from the University of California at Berkeley under the direction of Paul Bartlett. After studying asymmetric catalysis in the laboratories of David A. Evans at Harvard University as a National Science Foundation postdoctoral fellow, she joined the faculty at the University of Pennsylvania in 1997. Kozlowski is the recipient of a number of awards including a DuPont Young Investigator Award, an NSF Career Award, an Alfred P. Sloan Research Fellowship. The major focus of Professor Kozlowski’s research is the development of methods for the design of asymmetric catalysts.

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