Physical Chemistry for the Biosciences, 2nd Ed
Forthcoming 2024
Physical Chemistry for the Biosciences has been optimized for a one-semester course in physical chemistry for students of biosciences or a course in biophysical chemistry. Most students enrolled in this course have taken general chemistry, organic chemistry, and a year of physics and calculus.
Summary
Fondly known as “Baby Chang,” this best-selling text is ack in an updated second edition for the one-semester physical chemistry course. Carefully crafted to match the needs and interests of students majoring in the life sciences, Physical Chemistry for the Biosciences has been revised to provide students with a sophisticated appreciation for physical chemistry as the basis for a variety of interesting biological phenomena. Major changes to the new edition include:
- Discussion of intermolecular forces in chapter
- Detailed discussion of protein and nucleic acid structure, providing students with the background needed to fully understand the biological applications of thermodynamics and kinetics described later in the book
- Expanded and updated descriptions of biological examples, such as protein misfolding diseases, photosynthesis, and vision
Table of Contents
Preface
CHAPTER 1 Introduction
1.1 Nature of Physical Chemistry
1.2 Units
1.3 Atomic Mass, Molecular Mass, and the Chemical Mole
CHAPTER 2 Properties of Gases
2.1 Some Basic Definitions
2.2 An Operational Definition of Temperature
2.3 Ideal Gases
2.4 Real Gases
2.5 Condensation of Gases and the Critical State
2.6 Kinetic Theory of Gases
2.7 The Maxwell Distribution Laws
2.8 Molecular Collisions and the Mean Free Path
2.9 Graham’s Laws of Diffusion and Effusion
Problems
CHAPTER 3 Intermolecular Forces
3.1 Intermolecular Interactions
3.2 The Ionic Bond
3.3 Types of Intermolecular Forces
3.4 Hydrogen Bonding
3.5 The Structure and Properties of Water
3.6 Hydrophobic Interaction
Problems
CHAPTER 4 Biological Macromolecules
4.1 Structure of Proteins
4.2 Protein Stability
4.3 Protein Folding
4.4 Protein Misfolding Diseases
4.5 Structure of Nucleic Acids
4.6 Nucleic Acid Stability
4.7 The Ribosome
4.8 Methods for Determining Size, Shape, and Mass of Macromolecules
Problems
CHAPTER 5 The First Law of Thermodynamics
5.1 Work and Heat
5.2 The First Law of Thermodynamics
5.3 Heat Capacities
5.4 Gas Expansions
5.5 Calorimetry
5.6 Thermochemistry
5.7 Bond Energies and Bond Enthalpies
Problems
CHAPTER 6 The Second Law of Thermodynamics
6.1 Spontaneous Processes
6.2 Entropy
6.3 The Second Law of Thermodynamics
6.4 Entropy Changes
6.5 The Third Law of Thermodynamics
6.6 Gibbs Energy
6.7 Standard Molar Gibbs Energy of Formation (ΔfG◦m )
6.8 Dependence of Gibbs Energy on Temperature and Pressure
6.9 Phase Equilibria
6.10 Thermodynamics of Rubber Elasticity
6.11 Hydrophobic Interactions and the Entropy of Water
6.12 Thermodynamics of Protein Folding
Problems
CHAPTER 7 Solutions
7.1 Concentration Units
7.2 Partial Molar Quantities
7.3 The Thermodynamics of Mixing
7.4 Binary Mixtures of Volatile Liquids
7.5 Real Solutions
7.6 Colligative Properties
7.7 Electrolyte Solutions
7.8 Ionic Activity
7.9 Colligative Properties of Electrolyte Solutions
7.10 Biological Membranes
Appendix 7.1 Notes on Electrostatics
Problems
CHAPTER 8 Chemical Equilibrium
8.1 Chemical Equilibrium in Gaseous Systems
8.2 Reactions in Solutions
8.3 Heterogeneous Equilibria
8.4 Acid Base Equilibrium
8.5 The Influence of Temperature, Pressure, and Catalysts on the Equilibrium Constant
8.6 Binding of Ligands to Proteins
8.7 Bioenergetics
Appendix 8.1 Maintaining the pH of blood
Problems
CHAPTER 9 Electrochemistry
9.1 Electrochemical Cells
9.2 Single Electrode Potentials
9.3 Thermodynamics of Electrochemical Cells
9.4 Types of Electrochemical Cells
9.5 Applications of EMF Measurements
9.6 Biological Oxidation
9.7 ATP Synthase
9.8 Membrane Potential
Problems
CHAPTER 10 Chemical Kinetics
10.1 Reaction Rates
10.2 Reaction Order
10.3 Molecularity of a Reaction
10.4 More Complex Reactions
10.5 The Effect of Temperature on Reaction Rate
10.6 Potential-Energy Surfaces
10.7 Theories of Reaction Rates
10.8 Isotope Effects in Chemical Reactions
10.9 Reactions in Solution
10.10 Fast Reactions in Solution
10.11 Oscillating Solutions
Problems
CHAPTER 11 Enzyme Kinetics
11.1 General Principles of Catalysis
11.2 The Equations of Enzyme Kinetics
11.3 Chymotrypsin: A Case Study
11.4 Multisubstrate Systems
11.5 Enzyme Inhibition
11.6 pH Effects on Enzyme Kinetics
11.7 Ribonuclease A: A Case Study
Problems
CHAPTER 12 Quantum Mechanics and Atomic Structure
12.1 The Wave Theory of Light
12.2 Planck’s Quantum Theory
12.3 The Photoelectric Effect
12.4 Bohr’s Theory of the Hydrogen Emission Spectrum
12.5 de Broglie’s Postulate
12.6 The Heisenberg Uncertainty Principle
12.7 The Schrödinger Wave Equation
12.8 Particle in a One-Dimensional Box
12.9 Quantum Mechanical Tunneling
12.10 The Schrödinger Wave Equation for the Hydrogen Atom
12.11 Many-Electron Atoms and the Periodic Table
Problems
CHAPTER 13 The Chemical Bond
13.1 Lewis Structures
13.2 Valence Bond Theory
13.3 Hybridization of Atomic Orbitals
13.4 Electronegativity and Dipole Moment
13.5 Molecular Orbital Theory
13.6 Diatomic Molecules
13.7 Resonance and Electron Delocalization
13.8 Coordination Compounds
13.9 Coordination Compounds in Biological Systems
Problems
CHAPTER 14 Spectroscopy
14.1 Vocabulary
14.2 Microwave Spectroscopy
14.3 Infrared Spectroscopy
14.4 Electronic Spectroscopy
14.5 Nuclear Magnetic Resonance Spectroscopy
14.6 Electron Spin Resonance Spectroscopy
14.7 Fluorescence
14.8 Phosphorescence
14.9 Lasers
14.10 Optical Rotatory Dispersion and Circular Dichroism
Problems
CHAPTER 15 Photochemistry and Photobiology
15.1 Introduction
15.2 Photosynthesis
15.3 Vision
15.4 Biological Effects of Radiation
Problems
Appendix 1. Review of Mathematics
Appendix 2. Thermodynamic Data
Glossary
Index
Reviews
