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Biological Inorganic Chemistry

Ivano Bertini University of Florence
Harry B. Gray California Institute of Technology
Edward I. Stiefel Princeton University
Joan Selverstone Valentine University of California, Los Angeles
Subjects:

Organized and edited by Ivano Bertini, Harry Gray, Ed Stiefel, and Joan Valentine, with contributions from many other world leaders in the field, this all-new book is equally appropriate for graduate or senior undergraduate courses in bioinorganic chemistry. The book has been extensively class-tested at Princeton and UCLA, and it includes tutorials in biology and biochemistry and in inorganic chemistry to aid students of varying backgrounds.

Translated into Russian
ISBN 978-1-938787-96-6
eISBN 978-1-938787-01-0
766 pages, Copyright 2007, softbound.

Summary

The long awaited text for 21st century courses in biological inorganic chemistry is now available. Organized and edited by Ivano Bertini, Harry Gray, Ed Stiefel, and Joan Valentine, with contributions from many other world leaders in the field, this all-new book is equally appropriate for graduate or senior undergraduate courses in bioinorganic chemistry. The book has been extensively class-tested at Princeton and UCLA, and it includes tutorials in biology and biochemistry and in inorganic chemistry to aid students of varying backgrounds. The main text is divided into two parts. Part A, “Overviews of Biological Inorganic Chemistry,” sets forth the unifying principles of the field. A full course in bioinorganic chemistry could be based entirely on this overview section, which is a really a book within a book! Part B, “Metal-Ion Containing Biological Systems,” describes specific classes of systems in detail. A special feature is the strong connection to the genomic revolution that has dramatically enhanced our ability to define the function of gene products in living organisms. Throughout the book, protein data bank codes are given for structures discussed in the text, and students are encouraged to learn to use the PDB in their courses and research. This exciting new book will be a must read for years to come for all students and researchers interested in the field of biological inorganic chemistry.

Table of Contents

I  Introduction and Text Overview

PART A: OVERVIEWS OF BIOLOGICAL INORGANIC CHEMISTRY

II  Bioinorganic chemistry and the biogeochemical cycles
III  Metal ions and proteins: Binding, stability and folding
IV  Special cofactors and metal clusters
V  Transport and storage of metal ions in biology
VI  Biominerals and biomineralization
VII  Metals in medicine

PART B: METAL-ION CONTAINING BIOLOGICAL SYSTEMS

VIII  Metal ion transport and storage
IX  Hydrolytic chemistry
X  Electron transfer, respiration and photosynthesis
XI  Oxygen metabolism
XII  Hydrogen, carbon, nitrogen, and sulfur metabolism
XIII  Metalloenzymes with radical intermediates
XIV Metal ion receptors and signaling

TUTORIALS

Tutorial I  Cell biology, biochemistry and evolution
Tutorial II  Fundamentals of coordination chemistry

Appendices

Index

 

Preface

Metal ions play a unique role in biology. One of the grand challenges of the 21st century is to deduce how a specific sequence codes for a metalloprotein.  Such knowledge of genomic maps will contribute to the goal of understanding the molecular mechanisms of life. Specific annotations to a sequence often allude to the requirement of metals for protein function, but it is not yet possible to read that information from sequence alone. This increases the importance of the field of biological inorganic chemistry.

Knowledge coming from work at the interface of inorganic chemistry and biology has been growing so rapidly in recent years that it is impossible to capture it fully in a textbook. Nevertheless, with the help of many highly talented contributors, we have assembled a volume that we believe will be a valuable resource for students and researchers for years.

The book is divided into four parts: Part A, “Overviews of Biological Inorganic Chemistry”, sets forth the unifying principles of the field of Biological Inorganic Chemistry. Part B, “Metal-Ion Containing Biological Systems”, treats specific classes of systems in detail. The Tutorials are provided for those wishing to review some of the background in biology and inorganic chemistry. The Appendices provide additional information that will be of use to students in this field.  The volume edited by Que (see Appendix III) can be viewed as a companion to the current volume as it provides an introduction to the physical methods that have proven so powerful in elucidating structure and mechanism.

Contributors

Philip Aisen; Department of Physiology and Biophysics; Albert Einstein College of Medicine; Bronx, New York 10461

Michael W. Adams; Department of Biochemistry and Molecular Biology and Center for Metalloenzyme Studies; University of Georgia; Athens, Georgia 30602

Bruce A. Averill; Department of Chemistry; University of Toledo; Toledo, Ohio 43606

Gerald T. Babcock; Department of Chemistry; Michigan State University; East Lansing, Michigan 48828

Lucia Banci; Magnetic Resonance Center and Department of Chemistry; University of Florence; Sesto Fiorentino, Italy 50019

Helmut Beinert; Institute for Enzyme Research; University of Wisconsin; Madison, Wisconsin 53726

Ivano Bertini; Magnetic Resonance Center and Department of Chemistry; University of Florence; Sesto Fiorentino, Italy 50019

Joan B. Broderick; Department of Chemistry and Biochemistry; Montana State University; Bozeman, Montana 59717

Alison Butler; Department of Chemistry and Biochemistry; University of California, Santa Barbara; Santa Barbara, California 93106

Stefano Ciurli; Laboratory of Bioinorganic Chemistry; Department of Agro-Environmental Science and Technology; University of Bologna;  I-40127, Bologna, Italy

  1. A. Cowan; Chemistry; Ohio State University; Columbus, Ohio 43210

Valeria Culotta; Environmental Health Sciences; Johns Hopkins University School of Public Health; Baltimore, Maryland 21205

David M. Dooley; Department of Chemistry and Biochemistry; Montana State University; Bozeman, Montana 59717

Torbjörn Drakenberg; Department of Biophysical Chemistry; Lund University; 22100 Lund, Sweden

David J. Eide; Department of Nutritional Sciences; University of Wisconsin; Madison, Wisconsin 53706

Shelagh Ferguson-Miller; Biochemistry and Molecular Biology; Michigan State University; East Lansing, Michigan 48824

Bryan Finn; IT Department; Swedish University of Agricultural Sciences; S-23053 Alnarp, Sweden

Marc Fontecave; Université Joseph Fourier; CNRS–CEA; CEA–Grenoble; 38054 Grenoble, France

Sture Forsén; Department of Biophysical Chemistry, Lund University; 22100 Lund, Sweden

  1. David Garner; The School of Chemistry; The University of Nottingham; Nottingham NG7 2RD, United Kingdom

Edith B. Gralla; Department of Chemistry and Biochemistry; UCLA; Los Angeles, California 90095

Harry B. Gray; Beckman Institute; California Institute of Technology; Pasadena, California 91125

Hans-Juergen Hartmann; Anorganische Biochemie Physiologisch Chemisches Institut; University of Tübingen; Tübingen, Germany

James A. Ibers; Department of Chemistry; Northwestern University; Evanston, Illinois 60208

Geoffrey B. Jameson; Centre for Structural Biology; Institute of Fundamental Sciences, Chemistry; Massey University; Palmerston North, New Zealand

  1. Claire Kennedy;Department of Chemistry; Gannon University; Erie, Pennsylvania 16561

Judith Klinman; Departments of Chemistry and of Molecular and Cell Biology; University of California, Berkeley; Berkeley, California 94720

Jean LeGall; Instituto de Tecnologia Química e Biológica; Universidade Nova de Lisboa; Oeiras, Portugal

Peter F. Lindley; Instituto de Tecnologia Química e Biológica; Universidade Nova de Lisboa; Oeiras, Portugal

Yi Lu; Department of Chemistry; University of Illinois at Urbana-Champaign; Urbana, Illinois 61801

Claudio Luchinat; Magnetic Resonance Center and Department of Agricultural Biotechnology; University of Florence; Sesto Fiorentino, Italy 50019

Thomas J. Lyons; Department of Chemistry; University of Florida; Gainesville, Florida 32611

John S. Magyar; Beckman Institute; California Institute of Technology; Pasadena, California 91125

Stephen Mann; School of Chemistry; University of Bristol; Bristol BS8 1TS, United Kingdom

Michael J. Maroney; Department of Chemistry; University of Massachusetts, Amherst; Amherst, Massachusetts 01003

Jonathan McMaster; The School of Chemistry; The University of Nottingham; Nottingham NG7 2RD, United Kingdom

Christopher Muncie; School of Chemistry; University of Edinburgh; Edinburgh, United Kingdom

Aram Nersissian; Chemistry Department; Occidental College; Los Angeles, California 90041

William E. Newton; Department of Biochemistry; The Virginia Polytechnic Institute and State University; Blacksburg, Virginia 24061

Thomas V. O’Halloran; Chemistry Department; Northwestern University; Evanston, IL 60208

Thomas L. Poulos; Departments of Molecular Biology and Biochemistry, Chemistry, and Physiology and Biophysics; University of California, Irvine; Irvine, California 92617

Lawrence Que, Jr.; Department of Chemistry and Center for Metals in Biocatalysis; University of Minnesota; Minneapolis, Minnesota 55455

Stephen W. Ragsdale; Department of Biochemistry; University of Nebraska; Lincoln, Nebraska 68588

Keith Rickert; Department of Cancer Research WP26-462; Merck & Co.; P. O. Box 4; West Point, Pennsylvania 19486

James A. Roe; Department of Chemistry and Biochemistry; Loyola Marymount University; Los Angeles, California 90045

Roopali Roy; Department of Biochemistry and Molecular Biology and Center for Metalloenzyme Studies; University of Georgia; Athens, Georgia 30602

Peter J. Sadler; School of Chemistry; University of Edinburgh; Edinburgh, United Kingdom

Bibudhendra Sarkar; Structural Biology and Biochemistry; The Hospital for Sick Children and the University of Toronto; Toronto, Ontario M5G1X8 Canada

Bryan F. Shaw; Department of Chemistry and Biochemistry; UCLA; Los Angeles, California 90095

Michelle A. Shipman; School of Chemistry; University of Edinburgh; Edinburgh, United Kingdom

Edward I. Stiefel; Department of Chemistry; Princeton University; Princeton, New Jersey 08544

JoAnne Stubbe; Departments of Chemistry and Biology; Massachusetts Institute of Technology; Cambridge, Massachusetts 02139

Rudolf K. Thauer; Max-Planck Institut für Terrestrische Mikrobiologie; Phillips-Universitat Marburg; Marburg, Germany

Elizabeth C. Theil; Children’s Hospital Oakland Research Institute and the University of California, Berkeley; Oakland, California 94609

Paola Turano; Magnetic Resonance Center and Department of Chemistry; University of Florence; Sesto Fiorentino, Italy 50019

Joan Selverstone Valentine; Department of Chemistry and Biochemistry; UCLA; Los Angeles, California 90095

Ulrich Weser; Anorganische Biochemie Physiologisch Chemisches Institut; University of Tübingen; Tübingen, Germany

James W. Whittaker; Environmental and Biomolecular Systems; Oregon Health and Science University; Beaverton, Oregon 97006

Dennis R. Winge; Departments of Medicine and Biochemistry; University of Utah Health Sciences Center; Salt Lake City, Utah 84132

Jay R. Winkler; Beckman Institute; California Institute of Technology; Pasadena, California 91125

António V. Xavier; Instituto de Tecnologia Química e Biológica; Universidade Nova de Lisboa; Oeiras, Portugal

Charles Yocum; Chemistry and MCD Biology; University of Michigan; Ann Arbor, Michigan 48109

Shinya Yoshikawa; Department of Life Science; University of Hyogo; Kamigohri Akoh; Hyogo 678-1297, Japan

 

Other Content

Full TOC and frontmatter (pdf)

Reviews

“I heartily recommend this exciting book as an excellent senior-and graduate-level textbook as well as a reference source for both students and seasoned researchers alike. With its cutting-edge material, it should remain definitive many years to come.”
-Chem Educator

“A fantastic book that I can’t wait to get on my shelf.”
-Sonya J. Franklin, University of Iowa

“An indispensable book…Highly recommended for upper-division undergraduates through professionals.”
-Choice, July 07

“Excellent and comprehensive…appropriate for use both as a textbook and as a reference.”
-Kara Bren, University of Rochester

Ivano Bertini University of Florence

Ivano Bertini is Professor of Chemistry and Director of the Magnetic Resonance Center of the University of Florence. His main research interests are the advancements in nuclear magnetic resonance spectroscopy, the expression and preparation of metalloproteins, their structural characterization and the investigation of their interactions with emphasis on understanding cellular processes at the molecular level. He has over 600 papers and many books. He has received the Chugaev Diploma of Kurnakov Institute of the Academy of Science, URSS, in 1981, the Golden Medal of the Magnetic Resonance Group of the Italian Chemical Society, in 1991, Prize Accademia dei Lincei, Italy, in 1993, Bijvoet Medal, Utrecht, NL, in 1998, Sapio NMR Prize, Italy, in 1999 and the Cannizzaro Medal of the Italian Chemical Society and the Basolo Medal in 2006. Amongst the special lectures: A.D. Little Lecturer at MIT, Cambridge, MS, USA, in 1997, E.L. Mütterties Lecturer at Berkeley, CA, USA, in 1997 and FECS lecturer, Athens in 2002. He has received three honorary doctorates. He is a member of the Accademia Nazionale dei Lincei and of the Academia Europaea.

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Harry B. Gray California Institute of Technology

Harry Barkus Gray is the Arnold O. Beckman Professor of Chemistry and the Founding Director of the Beckman Institute at the California Institute of Technology. His main research interests center on inorganic spectroscopy, photochemistry, and bioinorganic chemistry, with emphasis on understanding electron transfer in proteins. For his contributions to chemistry, which include over 700 papers and 17 books, he has received the National Medal of Science from President Ronald Reagan (1986); the Linderstrøm-Lang Prize (1991); the Basolo Medal (1994); the Gibbs Medal (1994); the Chandler Medal (1999); the Harvey Prize (2000); the Nichols Medal (2003); the National Academy of Sciences Award in Chemical Sciences (2003); the Benjamin Franklin Medal in Chemistry (2004); the Wolf Prize in Chemistry (2004); the City of Florence Prize in Molecular Sciences (2006); six national awards from the American Chemical Society, including the Priestley Medal (1991); and 16 honorary doctorates. He is a member of the National Academy of Sciences; the American Academy of Arts and Sciences; the American Philosophical Society; an honorary member of the Italian Chemical Society; a foreign member of the Royal Danish Academy of Sciences and Letters; the Royal Swedish Academy of Sciences; and the Royal Society of Great Britain. He was California Scientist of the Year in 1988.

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Edward I. Stiefel Princeton University

Edward I. Stiefel, Professor of Chemistry at Princeton University and associated faculty member of the Princeton Environmental Institute until his untimely death in summer of 2006. His research involved the role of metal ions in biological systems including: iron in marine environments, especially the iron storage and DNA protective proteins ferritin and Dps; the biological production of hydrogen by phototropic hydrogenases and theoretical studies of hydrogenase action; the role of molybdenum in biology; and aspects of metals in medicine. He taught courses on the Elements of Life for freshman, Astrobiology for sophomores and Metals in Biology for advanced undergraduates and graduate students. He served on the Board of Reviewing Editors of Science and the Board of Editors of the Journal of Inorganic Biochemistry. Stiefel was the Sacconi Lecturer in Florence in 2002 and the Distinguished Lecturer at the University of Louisville in 2003 where he was named a Kentucky Colonel by the Governor of Kentucky. He won the American Chemical Society Award in Inorganic Chemistry for the year 2000. Ed Stiefel will be greatly missed by all who knew him.

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Joan Selverstone Valentine University of California, Los Angeles

Joan Selverstone Valentine is Professor of Chemistry and Biochemistry at UCLA.  She is a leading figure working at the interface of inorganic chemistry and biology and has published over 200 research papers and several books, and her work is widely cited. She pioneered the chemistry of the superoxide anion, and her discoveries have been fundamental to our understanding of the biological reactions of dioxygen and its interactions with metalloenzymes. Particularly notable in recent years are her demonstrations of the remarkable nucleophilic properties of iron porphyrin peroxo complexes, development of novel sol-gel techniques to entrap biological macromolecules in an optically transparent rigid matrix, and her ongoing detailed biophysical characterization of mutant copper-zinc superoxide dismutase enzymes that cause Lou Gehrig’s disease. She is a recipient of several awards, including the John C. Bailar, Jr. Medal, has held numerous distinguished lectureships in the United States and abroad, and was recently elected to membership in the National Academy of Science. She is Editor-in-Chief of Accounts of Chemical Research, an American Chemical Society journal.  

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